HOW DO THE OTHER SSRIS COMPARE TO PROZAC IN EFFICACY, SAFETY, AND SALE EFFECTS?

Two recently marketed SSRIs include Zoloft (generic name setraline) and Paxil (paroxetine). Both new drugs appear to be equal to Prozac in efficacy and safety. Like Prozac, Zoloft, Paxil and Luvox have minimal side effects, compared to the older tricyclics and MAOIs.

Both Zoloft and Paxil have shorter half-lives than Prozac, which suggests that on sudden withdrawal, there is a greater likelihood of producing symptoms than with Prozac, which tapers itself off over longer period of time.

Evidence indicates that all varieties of sexual side effects occur in approximately one third of all patients taking antidepressant medications, old and new.

How do Prozac and Wellbutrin compare to other antidepressants?

Prozac and Wellbutrin do not have the same mechanism of action. Wellbutrin works mainly by blocking the uptake of the neurotransmitters dopamine and norepinephrine in the brain; Prozac and other SSRIs work by blocking the uptake of serotonin.

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